pI: 7.098 |
Length (AA): 376 |
MW (Da): 41802 |
Paralog Number:
1
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
25 | 372 | 2b5e (A) | 22 | 346 | 20.00 | 0.0000000000047 | 0.97 | 1.02 | 0.4 |
26 | 288 | 2b5e (A) | 23 | 504 | 26.00 | 0 | 1 | 0.05 | 0.2 |
39 | 139 | 1nsw (A) | 4 | 100 | 31.00 | 0.000000000066 | 1 | 0.83 | -1.96 |
36 | 143 | 3wgx (A) | 190 | 294 | 37.00 | 0 | 1 | 0.938034 | -2.1 |
36 | 267 | 3idv (A) | 63 | 284 | 42.00 | 0 | 1 | 1.14282 | -0.65 |
37 | 366 | 4ekz (A) | 26 | 338 | 29.00 | 0 | 1 | 1.06446 | 0.64 |
57 | 125 | 3wgd (A) | 82 | 152 | 45.00 | 0.0000000055 | 1 | 0.801311 | -0.97 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127741)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G47470 | protein disulfide-isomerase like 2-1 |
Arabidopsis thaliana | AT2G32920 | protein disulfide-isomerase like 2-3 |
Arabidopsis thaliana | AT1G04980 | protein disulfide-isomerase like 2-2 |
Babesia bovis | BBOV_IV009100 | protein disulfide isomerase related protein |
Brugia malayi | Bm1_33495 | Probable protein disulfide isomerase A6 precursor, putative |
Candida albicans | CaO19.2516 | similar to N terminus of S. pombe SPAC17H9.14c putative protein disulfide isomerase |
Candida albicans | CaO19.10052 | similar to N terminus of S. pombe SPAC17H9.14c putative protein disulfide isomerase |
Caenorhabditis elegans | CELE_B0403.4 | Protein TAG-320 |
Caenorhabditis elegans | CELE_Y49E10.4 | Protein Y49E10.4 |
Cryptosporidium hominis | Chro.70453 | protein disulfide isomerase-related protein (provisional) |
Cryptosporidium parvum | cgd7_4080 | protein disulfide isomerase, signal peptide, ER retention motif |
Dictyostelium discoideum | DDB_G0276141 | protein disulfide isomerase |
Drosophila melanogaster | Dmel_CG5809 | calcium-binding protein 1 |
Echinococcus granulosus | EgrG_001002700 | protein disulfide isomerase A6 |
Entamoeba histolytica | EHI_071590 | protein disulfide isomerase, putative |
Echinococcus multilocularis | EmuJ_001002700 | protein disulfide isomerase A6 |
Homo sapiens | ENSG00000143870 | protein disulfide isomerase family A, member 6 |
Leishmania braziliensis | LbrM.26.0670 | protein disulfide isomerase, putative |
Leishmania donovani | LdBPK_260630.1 | protein disulfide isomerase, putative |
Leishmania infantum | LinJ.26.0630 | protein disulfide isomerase, putative |
Leishmania major | LmjF.26.0660 | protein disulfide isomerase, putative |
Leishmania mexicana | LmxM.26.0660 | protein disulfide isomerase, putative |
Loa Loa (eye worm) | LOAG_02996 | TAG-320 protein |
Mus musculus | ENSMUSG00000020571 | protein disulfide isomerase associated 6 |
Neospora caninum | NCLIV_065470 | hypothetical protein |
Oryza sativa | 4326806 | Os01g0339900 |
Oryza sativa | 4337858 | Os05g0156300 |
Oryza sativa | 4347226 | Os09g0451500 |
Plasmodium berghei | PBANKA_0914300 | protein disulfide isomerase related protein, putative |
Plasmodium falciparum | PF3D7_1134100 | protein disulfide isomerase |
Plasmodium knowlesi | PKNH_0932300 | protein disulfide-isomerase, putative |
Plasmodium vivax | PVX_092315 | protein disulfide isomerase, putative |
Plasmodium yoelii | PY06980 | Thioredoxin, putative |
Schistosoma japonicum | Sjp_0207350 | ko:K01829 protein disulfide-isomerase [EC5.3.4.1], putative |
Schistosoma mansoni | Smp_172110 | shc transforming protein |
Schmidtea mediterranea | mk4.001731.00 | Protein disulfide-isomerase A6 |
Schmidtea mediterranea | mk4.003196.02 | |
Trypanosoma brucei gambiense | Tbg972.7.1260 | protein disulfide isomerase, putative |
Trypanosoma brucei | Tb927.7.1300 | protein disulfide isomerase, putative |
Trypanosoma congolense | TcIL3000_7_920 | protein disulfide isomerase, putative |
Trypanosoma cruzi | TcCLB.508209.140 | protein disulfide isomerase, putative |
Trypanosoma cruzi | TcCLB.509505.10 | protein disulfide isomerase, putative |
Toxoplasma gondii | TGME49_249270 | protein disulfide isomerase-related protein (provisional), putative |
Theileria parva | TP01_0863 | protein disulfide isomerase, putative |
Trichomonas vaginalis | TVAG_277120 | protein disulfide isomerase, putative |
Trichomonas vaginalis | TVAG_117470 | protein disulfide isomerase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.1300 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1300 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1300 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.7.1300 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_B0403.4 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_249270 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | protein disulfide isomerase family A, member 6 | Compounds | References |